NEURoscience of Adult Language Research Lab
 

Research

We are interested in understanding language organization in the brain. We focus our research in older adults and adults with neurogenic communication disorders (e.g. aphasia).

Some recent publications from the lab…

  • Basilakos, A; Stark, BC; Johnson, L; Rorden, C; Yourganov, G; Bonilha, L & Fridriksson, J. (accepted). White matter small vessel disease is associated with decline in language among individuals with stroke-induced aphasia. Neurorehabilitation and Neural Repair.

  • Stark, B. C., Basilakos, A., Hickok, G., Rorden, C., Bonilha, L., & Fridriksson, J. (2019). Neural organization of speech production: A lesion-based study of error patterns in connected speech. Cortex, 117, 228–246. https://doi.org/10.1016/J.CORTEX.2019.02.029.

  • Stark, B. C. (in press). A comparison of three discourse elicitation methods in aphasia and age-matched adults: implications for language assessment and outcome. American Journal of Speech-Language Pathology.

 
 

Research Interests

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We use MRI to acquire high resolution images of the brain, which allows us to explore:

  • brain structure

  • brain function

  • relationship of brain structure and function with cognition

 

Language and the brain

Our specific area of interest is the organization of language in the brain.

We evaluate ‘language’ (a very wide topic!) in a variety of ways, specializing in:

  • Inner speech

  • Discourse production

  • Cognitive-linguistic tasks (e.g. executive function, attention, working memory)

  • Errors of morphology and grammar as well as single-word errors

SPOKEN DISCOURSE IN APHASIA

We are founders and members of the FOQUSAphasia (FOcusing on QUality of Spoken discourse in aphasia) working group. FOQUSAphasia is comprised of researchers and clinicians that value the evidence derived from spoken discourse during assessment and treatment of speakers with aphasia. The goal of FOQUSAphasia is to improve the state of research, which will directly translate into improved evidence-based practice for assessment and treatment of spoken discourse in aphasia.

Check out the group here, to join and to learn more about our efforts: https://www.foqusaphasia.com

ARE YOU A CLINICIAN OR RESEARCHER WHO COLLECTS SPOKEN DISCOURSE DATA FROM SPEAKERS WITH APHASIA? PLEASE TAKE OUR SURVEY: http://bit.ly/FOQUSAphasiaSurvey

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Research Facilities

We are located within Indiana University’s Department of Speech and Hearing Science

We work closely with Clinical Faculty in IU’s Speech-Hearing Clinic

Address:

200 S Jordan Avenue

Bloomington, IN 47405

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We collaborate closely with faculty and research scientists at Indiana University’s Psychological and Brain Sciences (PBS) Department

PBS houses our MRI facilities (Imaging Research Facility), including a 3T Siemens Prisma MR scanner

Address:

1101 E 10th St

Bloomington, IN 47405

 

 

Publications, Presentations and Funding

Publications

An updated list of publications can be found on Google Scholar


Presentations

RECENT Invited Lectures:

Stark, BC. Center for the Study of Aphasia Recovery, “From a single word to many words: Connected speech in aphasia.” bit.ly/cstarStark



 

Presentations:

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Stark, BC & Basilakos, A; Matchin, W; den Ouden, D; Hickok, G; Fridriksson, J. (2019). “Rating paragrammatism in speakers with aphasia: Methods and reliability.” American Speech-Language-Hearing Association Annual Convention, Orlando, FL.

den Ouden, D; Stark, BC; Basilakos, A; Matchin, WM; Hickok, G; Fridriksson, J. (2019) “Paragrammatism and agrammatism: a cortical double dissociation revealed by lesion-symptom mapping.” Poster. 57th Meeting of the Academy of Aphasia, Hong Kong.

Stark, BC; Marebwa, B; Basilakos, A; Philip, L; Thors, H; Yourganov, G; Rorden, C; Bonilha, L; Fridriksson, J (2019). “Neural architecture of discourse-derived fluency in post-stroke chronic aphasia.” Poster. Eleventh Meeting of the Society for the Neurobiology of Language, Helsinki, Finland.

Johnson, L; Wilson, SM; Yourganov, G; Basilakos, A; Stark, BC; Eriksson, DK; Newmna-Norlund, R; Rorden, C; Fridriksson, J. (2019). Neural synchronization during language processing in listeners with aphasia. Eleventh Meeting of the Society for the Neurobiology of Language, Helsinki, Finland.Matchin, W; Basilakos, A; den Ouden, D; Stark, BC; Fridriksson, J; Hickok, G. (2019). “Paragrammatism: a lesion-symptom mapping study.” 26th Annual Meeting of the Cognitive Neuroscience Society, San Francisco.

Marebwa, B; Wilmskoetter, J; Stark, BC; Johnson, LJ; Fridriksson, J; Bonilha, L. (2019). “The Impact of Brain Health and Long Range Cortical Disconnection on Stroke Recovery.” International Stroke Conference, Honolulu, HI

Fridriksson, J; Elm, J; Stark, BC; Basilakos, A; Rorden, C; Sen, S; George, MS; Bonilha, L. (2018). "BDNF Genotype and tDCS Interaction in Aphasia Therapy." NYC Neuromodulation NANS Summer Series.

Thors, H; Stark, BC; Yourganov, G; Basilakos, A; Fridriksson, J. (2018). "Analysis of functional connectivity furthers understanding of spontaneous speech and auditory comprehension in chronic stroke." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Kristinsson, K; Stark, BC; Yourganov, G; Basilakos, A; Thors, H; Fridriksson, J. (2018) " Neural Correlates of Sentence Processing in Acute Stroke Patients". Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Yourganov, G; Jefferson, J; Fridriksson, J; Stark, BC; Rorden, C. (2018). "Post-stroke impairment of auditory comprehension is associated with changes in cerebral blood flow." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Johnson, L; Basilakos, A; Stark, BC; Kristinsson, S; Bonilha, L; Rorden, C; Fridriksson, J. (2018). "Using white matter changes to predict naming outcomes after treatment in aphasia." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Wilmskoetter, J; Fridriksson, J; Gleichgerrcht, E; Stark, BC; Delgaizo, J; Hickok, G; Vaden, K; Hillis, AE; Rorden, C; Bonilha, L. (2018). "Neuroanatomical substrates of lexical retrieval." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Fridriksson, J; Elm, J; Stark, BC; Basilakos, A; Rorden, C; Sen, S; George, MS; Bonilha, L. (2018). "BDNF Genotype and tDCS Interaction in Aphasia Therapy." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Basilakos, A., Johnson, L., Bonilha, L., Stark, B., Rorden, C., Yourganov, G., Fridriksson, J. (2018). " The progression of leukoaraiosis predicts declines in language abilities: The role of brain health in chronic aphasia." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Stark, BC; Basilakos, A; Hickok, G; Rorden, C; Bonilha, L; Fridriksson, J. (2018). "The neural organization of speech production: A lesion-based study of error patterns in connected speech." Tenth Meeting of the Society for the Neurobiology of Language, Quebec, CA.

Stark, BC; Yourganov, G; Basilakos, A; Rorden, C; Bonilha, L; and Fridriksson, J (2017). "Behavior stability and reliability of fMRI activation in stroke aphasia." Poster presented at the Ninth Annual Meeting of the Society for the Neurobiology of Language, Baltimore, MD.

Stark, BC; Bonilha, L; Rorden, C and Fridriksson, J (2017). "Semantic naming errors are caused by temporo-occipital disconnection." Presentation at 46th Annual Clinical Aphasiology Conference, Snowbird, Utah, 2017.

Feenaughty, L; Basilakos, A; Bonilha, L; Rorden, C; Stark, BC and Fridriksson, J (2016). “Comparison of voxel-based lesion symptom maps for measures of speech fluency in chronic left-hemisphere stroke.” Poster presented at the Eighth Meeting of the Society for the Neurobiology of Language, London, UK.

Stark, BC; Geva, S and Warburton EA (2016). “Behavioral predictors of functional communication in post-stroke aphasia.” Poster presented at the Eighth Meeting of the Society for the Neurobiology of Language, London, UK.

Stark, BC and Warburton, EA (2015). “Computerized Aphasia Therapy in Chronic Aphasia: using self-administered iPad-delivered speech therapy to explore language improvements in post-stroke chronic expressive aphasia.” Presentation at European Stroke Conference, Vienna, Austria.

Stark, BC and Warburton, EA (2015). “Improvement after four weeks of self-delivered iPad speech therapy in post-stroke chronic expressive aphasia.” Presentation at Junior Investigator Symposium of the International Stroke Conference, Los Angeles, CA – could not attend

Stark, BC and Warburton, EA (2015). “Computerized Aphasia Therapy in Chronic Aphasia: using self-administered iPad-delivered speech therapy to explore language improvements in post-stroke chronic expressive aphasia.” (1st Prize) Poster presented at the Graduate School of Life Sciences, University of Cambridge, Cambridge UK.

Stark, BC and Thapar, A (2013). “Contributions of the frontal and medial temporal lobes to recognition memory performance in young adults.” Eastern Psychological Association Annual Meeting, New York City, NY – presented in abstentia by A Thapar.


Funding and Awards

funding

Awarded

Faculty Research Support Program Seed Funding (Funding period: 03/2018-03/2019, support: $30,128). Co-PI. In this project, we propose leveraging recent advances in network analysis to investigate the effect of stroke on functional connectivity and on cognitive-linguistic ability. To do this, we will acquire a novel MRI dataset (i.e. structural, functional, and diffusion) and neuropsychological dataset (i.e. language, executive function, working memory) from stroke survivors and typical, age-matched controls. Using biomarkers, such as structural connectivity and lesion volume, we will build computational models, trained on the typical control data, that predict the functional and cognitive consequences of stroke. We will then compare these predictive models to the actual data (i.e. the stroke group). This project will create translatable, clinical tools to improve understanding of prognosis for the cognitive consequences of stroke by modeling the importance of inter- individual biomarkers on cognitive ability.

Clinical and Translation Sciences Institute CORE Facilities Grant (Funding period: 03/2018-03/2020, support: $10,000). Co-PI. This funding supports the use of the Imaging Research Facility at Indiana University for acquisition of high-resolution MR images.

Pending

Early Career Research R21 [NIH NIDCD] (Funding period: 10/2019-10/2022, requested support: $451,149). This project will evaluate brain-behavior relationships, with an emphasis on spoken language production, in post-stroke and neurotypical aging adults. Combining clinical and cognitive neuroscience with network neuroscience, we will map the relationship of focal damage (i.e. stroke) to changes in brain connectivity,

and resultant impairments of language, thereby evaluating brain connectivity as a viable biomarker for improving prognostic accuracy and allowing for effective personalization of intervention.

ASHFoundation New Investigator Award (Funding period: 12/2019-1/2021, requested support: $10,000). This project will evaluate test-retest, inter-rater and intra-rater reliability of discourse-derived microlinguistic outcomes (e.g. structural properties of language) to improve on the use of discourse as an outcome in assessment and treatment studies in aphasia.

Completed Funding:

Gates Cambridge Trust (Funding period: 09/2012-06/2016, estimated support: $250,000). Following a competitive interview process, the Gates Cambridge Trust funded my doctoral work at the University of Cambridge, providing full tuition, room and board, as well as travel and conference stipends.

Awards

2019 - Lessons for Success, Research-Mentoring Network Program, American Speech-Language-Hearing Association

2018 - IUB Provost’s Travel Award for Women in Science

2017-2018 - Selected Mentee, Pathways Research-Mentoring Network Program, American Speech-Language-Hearing Association

2016 - Travel Award, Society for the Neurobiology of Language

2012 - Gates Cambridge Scholar

2009 - Howard Hughes Medical Institute Intern, PI: Dr. Paul Grobstein

 

 

Student Research

Undergraduates, Masters-level and PhD students complete research on language, communication and the brain!

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49th Clinical Aphasiology Conference in Whitefish, MT.

The NEURAL Research Lab members Dr. Stark and Manawswita contributed a roundtable discussion, a poster and a talk.

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Chandler Bright, Claflin University (undergrad)

Communicative Function in Aphasia

South Carolina Advancing Diversity in Aging Research

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J Malcolm Sutton, University of South Carolina (undergrad)

Examining Brain Damage Associated with Poor Reading Skills

2nd Place, Discover Day USC 2018

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Anna Grace Skipper & Sara Walden Hanna, University of South Carolina (Masters, MSP)

Examining the Relationship between Brain Lesion Site and Naming and Comprehension Ability Post-Stroke: A Dual Stream Model Investigation

1st Place, Discover Day USC 2018